Grenko R T, Gemryd P, Tytor M, Lundqvist P G, Boeryd B
Department of Pathology, University Hospital, Linköping, Sweden.
Histopathology. 1995 Mar;26(3):261-6. doi: 10.1111/j.1365-2559.1995.tb01440.x.
Twelve cases of salivary duct carcinoma were examined clinically, pathologically and by flow cytometry to quantify their histological features as well as attempt to identify factors predictive of patient outcome. All of the tumours arose in the parotid gland. Eight of the twelve patients were male. Four patients died of disease (median survival 12.5 months); three are alive with disease; and five are alive with no evidence of disease (mean follow-up of 50 months). Two tumours arose in a pre-existing pleomorphic adenoma. Positive lymph nodes were present in eight of ten patients sampled; patients with two or more positive lymph nodes tended to die of their disease or be alive with metastases. Comedo necrosis, perineural invasion and vascular invasion were common findings by light microscopy. Ten of the twelve tumours were aneuploid. Neither clinical stage, tumour size, aneuploidy nor histological features correlated with patient outcome. This study confirms the aggressive nature of salivary duct carcinoma.
对12例涎腺导管癌患者进行了临床、病理及流式细胞术检查，以量化其组织学特征，并试图确定预测患者预后的因素。所有肿瘤均发生于腮腺。12例患者中有8例为男性。4例患者死于疾病（中位生存期12.5个月）；3例患者带瘤生存；5例患者无疾病证据生存（平均随访50个月）。2例肿瘤发生于既往存在的多形性腺瘤中。在10例取样患者中，8例有阳性淋巴结；有两个或更多阳性淋巴结的患者往往死于疾病或带转移灶生存。通过光学显微镜检查，粉刺状坏死、神经周围浸润和血管浸润是常见表现。12例肿瘤中有10例为非整倍体。临床分期、肿瘤大小、非整倍体及组织学特征均与患者预后无关。本研究证实了涎腺导管癌的侵袭性。
