Kingsmore S F, Souryal C A, Watson M L, Patel D D, Seldin M F
Department of Medicine, University of Florida, Gainesville 32610-0221, USA.
Immunogenetics. 1995;42(1):59-62. doi: 10.1007/BF00164988.
By virtue of sequence similarity, the genes encoding CD2, CD48, CD58, and Ly-9 have been assigned to a distinct subset within the immunoglobulin superfamily. Previous gene mapping studies in human and mouse have suggested that CD2, CD48, and CD58 arose by gene duplication. Here we show the gene encoding Ly-9 to be located adjacent to CD48 and the Na,K-ATPase alpha 2 subunit gene on human and mouse chromosome 1. The proximity in human and mouse genomes of the genes encoding CD2, CD58, and the Na,K-ATPase alpha 1 subunit, and of the Ly-9, CD48, and the Na,K-ATPase alpha 2 subunit genes may be explained by the occurrence of two, successive duplication events during vertebrate evolution, and suggest that Ly-9 may also participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction.
由于序列相似性，编码CD2、CD48、CD58和Ly-9的基因已被归入免疫球蛋白超家族中的一个独特亚群。先前在人和小鼠中的基因定位研究表明，CD2、CD48和CD58是通过基因复制产生的。在此我们表明，编码Ly-9的基因位于人和小鼠1号染色体上与CD48及钠钾ATP酶α2亚基基因相邻的位置。编码CD2、CD58和钠钾ATP酶α1亚基的基因，以及Ly-9、CD48和钠钾ATP酶α2亚基基因在人和小鼠基因组中的接近程度，可能是由脊椎动物进化过程中发生的两次连续复制事件所解释的，这表明Ly-9也可能通过同源相互作用参与T淋巴细胞与辅助细胞之间的黏附反应。
