Omenaas E, Bakke P, Haukenes G, Hanoa R, Gulsvik A
Department of Thoracic Medicine, Gade Institute, University of Bergen, Norway.
Int J Epidemiol. 1995 Feb;24(1):223-31. doi: 10.1093/ije/24.1.223.
The aims were to examine prevalences as well as demographic and environmental predictors of respiratory virus antibodies in serum.
In a cross-sectional study of 18-73 year old Norwegian adults a random stratified sample (n = 1512) was invited to attend an examination at an outpatient clinic. Seven respiratory virus antibodies were assessed by the complement fixation test.
The attendance rate was 84%. The most frequent virus antibodies with titre of > or = 1:8 were influenza virus type A with a population standardized prevalence of 44%, adenovirus 25% and influenza virus type B 22%. The prevalences of antibodies against parainfluenza virus type 1, 2 and 3 increased with age. Smokers compared to non-smokers had an adjusted odds ratio (OR) of 1.7 (95% confidence interval [CI]: 1.3-2.4) for having one or more of the seven examined virus antibodies. The presence of one or more of the virus antibodies increased from summer to winter months (adjusted OR = 1.3 per month; 95% CI: 1.2-1.4) and it was higher in occupational dust or gas exposed smokers (adjusted OR = 2.0; 95% CI: 1.1-3.7) compared with unexposed smokers.
Ageing, smoking, occupational dust or gas exposure as well as season of the year may thus be predictors for levels of respiratory virus antibodies in adults. These observations should be taken into account when comparing prevalences of virus antibodies in various communities as well as when examining the relationship between presence of virus antibodies and airway disease.
目的是研究血清中呼吸道病毒抗体的流行率以及人口统计学和环境预测因素。
在一项针对18至73岁挪威成年人的横断面研究中，邀请了一个随机分层样本（n = 1512）到门诊诊所进行检查。通过补体结合试验评估七种呼吸道病毒抗体。
出勤率为84%。滴度≥1:8的最常见病毒抗体是甲型流感病毒，人群标准化流行率为44%，腺病毒为25%，乙型流感病毒为22%。1型、2型和3型副流感病毒抗体的流行率随年龄增加而升高。与不吸烟者相比，吸烟者拥有七种检测病毒抗体中一种或多种的校正比值比（OR）为1.7（95%置信区间[CI]：1.3 - 2.4）。从夏季到冬季，一种或多种病毒抗体的存在增加（每月校正OR = 1.3；95% CI：1.2 - 1.4），并且与未接触职业性粉尘或气体的吸烟者相比，接触职业性粉尘或气体的吸烟者中病毒抗体的存在更高（校正OR = 2.0；95% CI：1.1 - 3.7）。
因此，年龄、吸烟、职业性粉尘或气体暴露以及一年中的季节可能是成年人呼吸道病毒抗体水平的预测因素。在比较不同社区病毒抗体的流行率以及检查病毒抗体的存在与气道疾病之间的关系时，应考虑这些观察结果。
