McCullagh P
Aust J Exp Biol Med Sci. 1976 Oct;53(5):399-411. doi: 10.1038/icb.1975.45.
The resistance of neonatal rats to sustaining adoptive immune responses against heterologous erythrocytes following the transfter of normal thoracic dust lymphocytes was examined. Irradiation of the neonatal rat at levels as low as 350 rad was found to be effective in overcoming this resistance, although preliminary exposure to antigen could interfere with facilitation of adoptive responses by irradiation. It is suggested that the failure of the neonate to sustain adoptive immune responses is explicable on the basis of an active suppression and, as a corollary, unresponsiveness resulting either from macrophage immaturity or the transfer of maternal antibody is discountered as a likely explanation for the immunological behavior of the newborn rat towards the antigens examined.
对新生大鼠在输注正常胸导管淋巴细胞后维持针对异种红细胞的过继免疫反应的抵抗力进行了检测。发现低至350拉德的辐照剂量对新生大鼠有效，可克服这种抵抗力，尽管预先接触抗原有可能干扰辐照对过继反应的促进作用。有人提出，新生大鼠不能维持过继免疫反应可基于一种主动抑制来解释，并且作为一个必然结果，由巨噬细胞不成熟或母源抗体转移导致的无反应性作为新生大鼠针对所检测抗原的免疫行为的一种可能解释而被排除。
