Van der Gaag R, McCullagh P
Aust J Exp Biol Med Sci. 1976 Oct;53(5):421-9. doi: 10.1038/icb.1975.47.
The intravenous injection of as few as 15 Walker tumour cells into newborn rats consistently resulted in the development of pulmonary metastases and the death of the recipient within 2 weeks. Neither the outcome of tumour cell injection nor the interval until death could be modified by transferring 2 x 10(7) lymphocytes from tumour-immune adult rats to the neonataal hosts. In contrast with this failure to transfer adoptive anti-tumour immune responses to intact recipients, the administration of 350 rad irradiation before transfer of 10(6) immune lymphocytes constantly afforded protection against inoculated tumour cells. The simultaneous transfer of neonatal thymus cells with immune lymphocytes interfered with the establishment of an adoptive response in the irradiated newborn. Intiation of a graft-versus-host response in F1 hybrid neonates by injecting parental strain lymphocytes conferred resistance to tumour growth of the recpient, the magnitude of this effect increasing with the strength of the graft-versus-host reaction.
给新生大鼠静脉注射少至15个沃克肿瘤细胞，始终会导致肺转移的发生以及受体在2周内死亡。将来自对肿瘤免疫的成年大鼠的2×10⁷个淋巴细胞转移至新生宿主，既不能改变肿瘤细胞注射的结果，也不能改变直至死亡的间隔时间。与无法将过继性抗肿瘤免疫反应转移至完整受体相反，在转移10⁶个免疫淋巴细胞之前给予350拉德辐射，持续为接种的肿瘤细胞提供了保护。将新生胸腺细胞与免疫淋巴细胞同时转移，会干扰经辐射的新生儿中过继性反应的建立。通过注射亲代品系淋巴细胞在F1杂交新生儿中引发移植物抗宿主反应，赋予了受体对肿瘤生长的抗性，这种效应的程度随着移植物抗宿主反应的强度增加而增加。
