初次免疫6年后水痘疫苗加强剂量的安全性及细胞和体液免疫反应
Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization.
作者信息
Watson B, Rothstein E, Bernstein H, Arbeter A, Arvin A, Chartrand S, Clements D, Kumar M L, Reisinger K, Blatter M
机构信息
Division of Allergy, Immunology, and Infectious Diseases, Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, PA 19104, USA.
出版信息
J Infect Dis. 1995 Jul;172(1):217-9. doi: 10.1093/infdis/172.1.217.
Four hundred nineteen children and adolescents immunized with live varicella vaccine 4-6 years earlier were enrolled in a study to evaluate the safety and immune response to a booster dose containing approximately 3300 pfu of virus. Of the subjects, 99% (414/419) maintained antibody to varicella zoster virus (VZV) with a geometric mean titer of 25.7 and mean stimulation index (SI) for VZV-specific lymphoproliferation response of 40.3 +/- 5.3 (SE). Some 7-10 days after the booster immunization, seropositivity rates increased to 100% (302/302), and GMT was 143.6 (anamnestic response). At 6 weeks after the booster inoculation, a subset of subjects had 100% seropositivity (74/74) with a GMT of 218.8 and an SI of 58.6. After 3 months, seropositivity was 100% (358/358), GMT was 119.0, and SI was 61.4.
419名4至6年前接种过水痘减毒活疫苗的儿童和青少年参与了一项研究，以评估对含约3300个病毒空斑形成单位（pfu）的加强剂量疫苗的安全性和免疫反应。在这些受试者中，99%（414/419）保持了对水痘带状疱疹病毒（VZV）的抗体，几何平均滴度为25.7，VZV特异性淋巴细胞增殖反应的平均刺激指数（SI）为40.3±5.3（标准误）。加强免疫后约7至10天，血清阳性率升至100%（302/302），几何平均滴度为143.6（回忆反应）。加强接种后6周，一部分受试者血清阳性率为100%（74/74），几何平均滴度为218.8，刺激指数为58.6。3个月后，血清阳性率为100%（358/358），几何平均滴度为119.0，刺激指数为61.4。
Zotero 插件