Garvey M J, Hollon S D, DeRubeis R J
Department of Psychiatry, VA Medical Center, Iowa City, IA.
J Affect Disord. 1994 Sep;32(1):45-50. doi: 10.1016/0165-0327(94)90060-4.
Forty-eight unipolar depressed patients were randomly assigned to 12 weeks of treatment with either imipramine (IMI) (n = 32) or cognitive therapy (CT) (n = 16). Prior to treatment assignment, all patients were rated for severity of a variety of psychosocial stressors. The interaction effect between pretreatment stress and type of treatment, CT or IMI, on symptom improvement was evaluated. We hypothesized that patients with greater pretreatment stress would respond better to cognitive therapy. Patients treated with either CT or IMI showed equivalent reductions of depressive symptoms. There was no interaction effect between pretreatment stress and type of treatment on improvement of depressive symptoms. Based on this preliminary study it does not appear that depressed patients with higher pretreatment levels of stress respond better to cognitive therapy than they do to imipramine.
48名单相抑郁症患者被随机分配接受为期12周的丙咪嗪（IMI）治疗（n = 32）或认知疗法（CT）治疗（n = 16）。在分配治疗前，对所有患者的各种心理社会应激源的严重程度进行了评估。评估了治疗前应激与治疗类型（CT或IMI）之间对症状改善的交互作用。我们假设治疗前应激较大的患者对认知疗法的反应会更好。接受CT或IMI治疗的患者抑郁症状均有同等程度的减轻。治疗前应激与治疗类型之间对抑郁症状改善没有交互作用。基于这项初步研究，似乎治疗前应激水平较高的抑郁症患者对认知疗法的反应并不比对丙咪嗪的反应更好。
