Watkins J T, Leber W R, Imber S D, Collins J F, Elkin I, Pilkonis P A, Sotsky S M, Shea M T, Glass D R
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center.
J Consult Clin Psychol. 1993 Oct;61(5):858-64. doi: 10.1037//0022-006x.61.5.858.
Two hundred fifty moderately to severely depressed outpatients were randomly assigned to 16 weeks of cognitive-behavioral therapy, interpersonal psychotherapy, imipramine plus clinical management (IMI-CM), or pill placebo plus clinical management. Two hundred thirty-nine patients actually began treatment. The most rapid change in depressive symptoms occurred in the IMI-CM condition, which achieved significantly better results than the other treatments at 8 and 12 weeks on 1 or more variables. Change over the course of treatment on variables hypothesized to be most specifically affected by the respective treatments was found only in the case of pharmacotherapy, in which imipramine produced significantly greater changes on the endogenous measure at 8 and 12 weeks.
250名中度至重度抑郁症门诊患者被随机分配接受为期16周的认知行为疗法、人际心理疗法、丙咪嗪加临床管理（IMI-CM）或安慰剂加临床管理。239名患者实际开始治疗。抑郁症状改善最快的是IMI-CM组，在8周和12周时，该组在1个或更多变量上的治疗效果显著优于其他治疗组。仅在药物治疗组中发现，在假设受各自治疗影响最显著的变量上，治疗过程中有变化，丙咪嗪在8周和12周时在内源性指标上产生了显著更大的变化。
