Yosipovitch G, Reis J, Tur E, Blau H, Harell D, Morduchowicz G, Boner G
Department of Medicine B, Beilinson Medical Center, Petah Tiqva, Israel.
J Lab Clin Med. 1994 Dec;124(6):808-12.
The sweat gland has some similarity with the convoluted tubules of the kidney. Little is known about sweat secretion and electrolyte content of sweat in the uremic gland. A pilocarpine ionotophoresis sweat test was performed in 40 patients with advanced renal failure (RF). Sweat secretion was measured and analyzed for Na, K, and Cl and correlated to blood parameters, type, and duration of dialysis. The sweat weight was significantly lower in all RF patients when compared with this parameter in healthy controls (p < 0.0001). No difference was noted between patients undergoing hemodialysis, those undergoing continuous ambulatory peritoneal dialysis, and those not undergoing dialysis. Men sweated more than women among RF patients and among controls (p < 0.0001). An inverse correlation was found between sweat weight and blood calcium levels (p < 0.001). Sweat K concentration was significantly higher (p < 0.0001) in patients with RF than in healthy controls, while the concentrations of Na and Cl were similar. Several mechanisms are suggested as possible explanations for these changes.
汗腺与肾曲小管有一些相似之处。关于尿毒症患者汗腺的汗液分泌及汗液电解质含量，人们所知甚少。对40例晚期肾衰竭（RF）患者进行了毛果芸香碱离子透入汗液试验。测量并分析了汗液分泌情况以及汗液中的钠、钾和氯含量，并将其与血液参数、透析类型及透析时间进行关联分析。与健康对照组相比，所有RF患者的汗液重量均显著降低（p < 0.0001）。接受血液透析的患者、接受持续性非卧床腹膜透析的患者以及未接受透析的患者之间未发现差异。在RF患者和对照组中，男性出汗均多于女性（p < 0.0001）。发现汗液重量与血钙水平呈负相关（p < 0.001）。RF患者汗液中的钾浓度显著高于健康对照组（p < 0.0001），而钠和氯的浓度相似。文中提出了几种机制作为这些变化的可能解释。
