Rigter H, Popping A
Psychopharmacologia. 1976 Apr 15;46(3):255-61. doi: 10.1007/BF00421111.
Conditioned taste aversion for a 5% glucose solution (sugar water) was induced in rats by an i.p. injection of LiCl 30 min after the first presentation of sugar water. Extinction of conditioned taste aversion was measured either in the forced-drinking test or in the preference-drinking test. In the forced-drinking test sugar water was the only fluid presented to the animals during extinction sessions. In the preference-drinking test the animals had the choice of tap water or sugar water. The rate of extinction was much slower in the preference test. The ACTH-analogues, ACTH 4-10 and ACTH 4-10 7d Phe, and alpha-MSH delayed extinction in the preference test but not extinction in the forced-drinking test. ACTH 11-24 was without any effect. MSH-release inhibiting factor (MIF) facilitated extinction in the forced-drinking test but did not alter extinction in the preference test. The peptides did not affect intake of tap water of preference of sugar water over tap water by control rats.
在大鼠首次接触5%葡萄糖溶液（糖水）30分钟后，通过腹腔注射氯化锂诱导其对糖水产生条件性味觉厌恶。在强制饮水试验或偏好饮水试验中测量条件性味觉厌恶的消退情况。在强制饮水试验中，在消退阶段向动物提供的唯一液体是糖水。在偏好饮水试验中，动物可以选择自来水或糖水。在偏好试验中，消退速度要慢得多。促肾上腺皮质激素类似物促肾上腺皮质激素4-10和促肾上腺皮质激素4-10 7d苯丙氨酸，以及α-促黑素在偏好试验中延迟了消退，但在强制饮水试验中没有延迟消退。促肾上腺皮质激素11-24没有任何作用。促黑素释放抑制因子（MIF）在强制饮水试验中促进了消退，但在偏好试验中没有改变消退情况。这些肽不影响对照大鼠的自来水摄入量或糖水相对于自来水的偏好。
