Kuramoto K
Tokyo Metropolitan Geriatric Hospital, Japan.
J Hypertens Suppl. 1994 Sep;12(6):S35-40.
Data collected from post-mortem information at the Tokyo Metropolitan Geriatric Hospital showed that the overall prevalence of hypertension in Japanese patients aged over 60 years was 53%; one-third of these elderly hypertensives had isolated systolic hypertension. Isolated systolic and systolodiastolic hypertension were each associated with a similar degree of increased atherosclerosis and cardiovascular complications. In a placebo-controlled study antihypertensive treatment produced a reduction in withdrawal from treatment in elderly patients with mild hypertension. INTERIM TRIAL RESULTS: Some interim results have been obtained from a new trial which is currently under way in Japan, the National Intervention Cooperative Study for the Treatment of Elderly Hypertensives, a long-term study comparing the effects of a calcium antagonist (nicardipine) and a thiazide diuretic (trichlormethiazide) on cardiovascular complications in elderly patients with mild to moderate hypertension.
从东京都老人医院尸检信息收集的数据显示，60岁以上日本患者高血压总体患病率为53%；这些老年高血压患者中有三分之一患有单纯收缩期高血压。单纯收缩期高血压和收缩期舒张期高血压均与动脉粥样硬化和心血管并发症的相似程度增加相关。在一项安慰剂对照研究中，降压治疗降低了轻度高血压老年患者的治疗退出率。中期试验结果：目前正在日本进行一项新试验，即全国老年高血压治疗干预合作研究，这是一项长期研究，比较钙拮抗剂（尼卡地平）和噻嗪类利尿剂（三氯噻嗪）对轻度至中度高血压老年患者心血管并发症的影响，现已获得一些中期结果。
