Kotaniemi A, Isomäki H, Hakala M, Risteli L, Risteli J
Rheumatism Foundation Hospital, Heinola, Finland.
J Rheumatol. 1994 Sep;21(9):1593-6.
To evaluate the serum concentration of the mature, crosslinked carboxy terminal telopeptide of type I collagen (ICTP) in patients with early onset rheumatoid arthritis (RA) and to assess its correlation with clinically relevant features of the disease.
The serum ICTP concentration was measured in 99 adult patients with RA with a duration of disease less than one year. The main clinical outcome measures were joint count, modified Lansbury index, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Larsen index and number of erosions in peripheral joints.
There was a strong positive correlation (p < 0.001) between the serum ICTP concentration and the Lansbury joint index and a weaker but still significant correlation (p < 0.01) between the serum ICTP concentration and the number of eroded hand and foot joints.
Serum ICTP may have value as a marker of tissue destruction in patients with early RA.
评估早发型类风湿关节炎（RA）患者血清中成熟的、交联的I型胶原羧基末端肽（ICTP）浓度，并评估其与该疾病临床相关特征的相关性。
对99例病程少于1年的成年RA患者测定血清ICTP浓度。主要临床结局指标包括关节计数、改良兰斯伯里指数、红细胞沉降率（ESR）、C反应蛋白（CRP）、拉森指数及外周关节侵蚀数量。
血清ICTP浓度与兰斯伯里关节指数之间存在强正相关（p < 0.001），血清ICTP浓度与手足关节侵蚀数量之间存在较弱但仍显著的相关性（p < 0.01）。
血清ICTP可能作为早期RA患者组织破坏的标志物具有价值。
