I型胶原蛋白降解增加与类风湿关节炎的疾病严重程度相关。
Increased type I collagen degradation correlates with disease severity in rheumatoid arthritis.
作者信息
Hakala M, Risteli L, Manelius J, Nieminen P, Risteli J
机构信息
Päivärinne Hospital, Muhos, Finland.
出版信息
Ann Rheum Dis. 1993 Dec;52(12):866-9. doi: 10.1136/ard.52.12.866.
OBJECTIVES
To assess the extent and clinical significance of type I collagen degradation in rheumatoid arthritis (RA).
METHODS
Serum samples from 90 consecutive patients with RA from a cross-sectional population based study and 90 age- and sex-matched controls were analysed with the new assay of cross-linked carboxyterminal telopeptide of type I collagen (ICTP).
RESULTS
Patients with RA had significantly higher concentrations of ICTP than the controls. ICTP correlated strongly with measures of impairment in RA, such as the erosive state of joint disease (ES) (r = 0.57, p < 0.001) and Keitel function test (KFT) (r = 0.49, p < 0.001), and more weakly with various disease activity markers. When erythrocyte sedimentation rate (ESR), ES or KFT were used as indicators of disease severity among the patients with disease duration over five years, ICTP distinguished the more serious RA from milder cases.
CONCLUSIONS
Elevated serum concentrations of ICTP are common in RA and are associated with signs of aggressive disease.
目的
评估类风湿关节炎（RA）中I型胶原降解的程度及临床意义。
方法
采用新的I型胶原交联羧基末端肽（ICTP）检测方法，对来自一项基于横断面人群研究的90例连续RA患者以及90例年龄和性别匹配的对照者的血清样本进行分析。
结果
RA患者的ICTP浓度显著高于对照组。ICTP与RA的损伤指标密切相关，如关节疾病的侵蚀状态（ES）（r = 0.57，p < 0.001）和凯特尔功能试验（KFT）（r = 0.49，p < 0.001），与各种疾病活动标志物的相关性较弱。当将红细胞沉降率（ESR）、ES或KFT用作病程超过五年患者疾病严重程度的指标时，ICTP能区分病情较重的RA与较轻病例。
结论
RA患者血清ICTP浓度升高很常见，且与侵袭性疾病的体征相关。
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