Makino Y, Tanaka H, Nakamura K, Fujita M, Akiyama K, Makino I
Second Department of Internal Medicine, Asahikawa Medical College, Japan.
J Rheumatol. 1994 Sep;21(9):1771-2.
A 27-year-old man with psoriasis was administered with leukocyte derived interferon-alpha for the treatment of chronic persistent hepatitis C. After 3 weeks of injections and eventual normalization of serum levels of alanine aminotransferase, he began to experience polyarthritis, with worsening of psoriatic skin lesions. Tests for antinuclear antibodies and rheumatoid factor were negative, indicating a direct association between interferon therapy and occurrence of seronegative arthritis.
一名患有银屑病的27岁男性接受白细胞衍生的α干扰素治疗慢性持续性丙型肝炎。在注射3周后，血清丙氨酸转氨酶水平最终恢复正常，他开始出现多关节炎，同时银屑病皮肤病变加重。抗核抗体和类风湿因子检测均为阴性，表明干扰素治疗与血清阴性关节炎的发生之间存在直接关联。
