Georgetson M J, Yarze J C, Lalos A T, Webster G F, Martin P
Department of Gastroenterology and Hepatology, Guthrie Clinic, Sayre, Pennsylvania.
Am J Gastroenterol. 1993 Oct;88(10):1756-8.
Interferon-alpha is an immune modulating drug which is indicated for the treatment of chronic viral hepatitis B and C. Several previous reports have suggested an association between treatment of patients with interferon-alpha and the development or exacerbation of autoimmune diseases. We report two patients with chronic viral hepatitis in whom treatment with interferon-alpha was associated with dramatic worsening of previously diagnosed psoriasis, necessitating discontinuation of the drug.
