预防性抗生素治疗与心脏瓣膜置换术。
Prophylactic antibiotic therapy and heart valve replacement.
作者信息
Austin T W, Coles J C, Finley R, Schieven B
出版信息
Can J Surg. 1976 Jul;19(4):349-52.
PMID:779941
Abstract
Patients undergoing cardiac bypass for heart valve replacement maintained adequate blood concentrations of cloxacillin throughout the duration of bypass, provided their initial blood concentration was in the therapeutic range. Blood levels related to the time between the last preoperative dose of antibiotic and operation. Maximal values were achieved if an intraoperative bolus of drug was given.
摘要
接受心脏搭桥术进行心脏瓣膜置换的患者，只要其初始血药浓度在治疗范围内，在整个搭桥过程中就能维持足够的氯唑西林血药浓度。血药浓度与术前最后一剂抗生素给药时间和手术时间相关。若术中给予一次大剂量药物，则可达到最大值。
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