Goulet J R, Kinkel A W, Smith T C
Clin Pharmacol Ther. 1976 Aug;20(2):213-8. doi: 10.1002/cpt1976202213.
Twenty subjects, in a double-blind, controlled, rising dose study, were given ethosuximide either once daily or 3 times daily. Steady-state plasma levels and urinary throughput were proportional to dose and were equivalent whether the daily dose was given as a single or divided dose. This finding adds validity to consideration of the single daily dose regimen as a therapeutic possiblity. The metabolic principles should be considered both in patient management and in the treatment of overdosage.
