• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Nonstereoselective disposition of ethosuximide in humans.

作者信息

Villén T, Bertilsson L, Sjöqvist F

机构信息

Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Sweden.

出版信息

Ther Drug Monit. 1990 Sep;12(5):514-6. doi: 10.1097/00007691-199009000-00018.

DOI:10.1097/00007691-199009000-00018
PMID:2293417
Abstract

The total concentration of ethosuximide varied between 80 and 770 mumol/L in plasma samples obtained from 33 patients on long-term treatment with the racemic drug. The ratios between the two enantiomers measured by chiral gas chromatography in the same samples were close to unity (mean +/- SD = 1.06 +/- 0.14; range = 0.76-1.39). This suggests that the disposition of ethosuximide in humans is not stereoselective and that the measurement of total concentrations of ethosuximide is sufficient for therapeutic monitoring.

摘要

相似文献

1
Nonstereoselective disposition of ethosuximide in humans.
Ther Drug Monit. 1990 Sep;12(5):514-6. doi: 10.1097/00007691-199009000-00018.
2
[Therapeutic drug monitoring of ethosuximide].[乙琥胺的治疗药物监测]
Nihon Rinsho. 1990 Feb;48 Suppl:1109-11.
3
Ethosuximide enantiomers in pregnancy and lactation.妊娠和哺乳期的乙琥胺对映体
Ther Drug Monit. 1994 Dec;16(6):621-3. doi: 10.1097/00007691-199412000-00016.
4
The pharmacokinetics of ethosuximide enantiomers in the rat.
Biopharm Drug Dispos. 2001 Mar;22(2):83-9. doi: 10.1002/bdd.266.
5
Improved control of epilepsy by monitoring plasma ethosuximide.通过监测血浆乙琥胺改善癫痫控制
Arch Neurol. 1973 Mar;28(3):178-81. doi: 10.1001/archneur.1973.00490210058007.
6
Factors influencing plasma concentrations of ethosuximide.
Clin Pharmacokinet. 1979 Jan-Feb;4(1):38-52. doi: 10.2165/00003088-197904010-00004.
7
Ethosuximide plasma concentrations: influence of age and associated concomitant therapy.乙琥胺血浆浓度：年龄及相关伴随治疗的影响
Clin Pharmacokinet. 1982 Mar-Apr;7(2):176-80. doi: 10.2165/00003088-198207020-00006.
8
Quantification of urinary excretion of ethosuximide enantiomers and their major metabolites in the rat.大鼠体内乙琥胺对映体及其主要代谢物尿排泄量的定量分析。
Biopharm Drug Dispos. 2001 Apr;22(3):129-36. doi: 10.1002/bdd.265.
9
The determination of ethosuximide in serum by gas chromatography. Preliminary results of clinical application.气相色谱法测定血清中乙琥胺。临床应用初步结果。
Clin Chim Acta. 1971 Jun;33(1):87-90. doi: 10.1016/0009-8981(71)90253-1.
10
Simultaneous quantitative gas-chromatographic analysis of ethosuximide, phenobarbitone, primidone and diphenylhydantoin.乙琥胺、苯巴比妥、扑米酮和苯妥英的同步定量气相色谱分析。
Br J Clin Pharmacol. 1976 Feb;3(1):145-50. doi: 10.1111/j.1365-2125.1976.tb00581.x.

引用本文的文献

1
Ethosuximide: from bench to bedside.乙琥胺：从实验室到临床应用
CNS Drug Rev. 2007 Summer;13(2):224-39. doi: 10.1111/j.1527-3458.2007.00009.x.
2
Bioequivalence of chiral drugs. Stereospecific versus non-stereospecific methods.手性药物的生物等效性。立体特异性方法与非立体特异性方法。
Clin Pharmacokinet. 1997 Aug;33(2):122-41. doi: 10.2165/00003088-199733020-00004.
3
The metabolism of ethosuximide.
Eur J Drug Metab Pharmacokinet. 1993 Oct-Dec;18(4):349-53. doi: 10.1007/BF03190184.