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The metabolism of ethosuximide.

作者信息

Millership J S, Mifsud J, Collier P S

机构信息

School of Pharmacy, Queen's University of Belfast, UK.

出版信息

Eur J Drug Metab Pharmacokinet. 1993 Oct-Dec;18(4):349-53. doi: 10.1007/BF03190184.

DOI:10.1007/BF03190184
PMID:8020533
Abstract

The metabolism of the antiepileptic drug ethosuximide (3-ethyl-3-methylpyrollidine-2,5-dione) (I) in animals and humans is reviewed. Chiral aspects of the metabolism of ethosuximide are discussed. Clarification of the precise nature of the hydroxymetabolites of ethosuximide is presented.

摘要

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本文引用的文献

1
Identification of 2-ethyl-2-methyl-3-hydroxysuccinimide as a major metabolite of ethosuximide in humans.
J Pharm Sci. 1974 Mar;63(3):467-9. doi: 10.1002/jps.2600630339.
2
Metabolism of 2-ethyl-2-methylsuccinimide (ethosuximide) in the rat and human.
Drug Metab Dispos. 1973 May-Jun;1(3):569-76.
3
Nonstereoselective disposition of ethosuximide in humans.
Ther Drug Monit. 1990 Sep;12(5):514-6. doi: 10.1097/00007691-199009000-00018.
4
Metabolism of ethosuximide.
Clin Pharmacol Ther. 1976 Aug;20(2):213-8. doi: 10.1002/cpt1976202213.
5
Urinary metabolites of 2-ethyl-2-methylsuccinimide (ethosuximide) studied by combined gas chromatography mass spectrometry.
Biomed Mass Spectrom. 1978 Nov;5(11):601-3. doi: 10.1002/bms.1200051102.