Kubena L F, Smith E E, Gentles A, Harvey R B, Edrington T S, Phillips T D, Rottinghaus G E
USDA, Agricultural Research Service, Food Animal Protection Research Laboratory, College Station, Texas 77845.
Poult Sci. 1994 Sep;73(9):1390-7. doi: 10.3382/ps.0731390.
The effects of feeding 6 mg T-2 toxin (T-2) and 34 mg cyclopiazonic acid (CPA)/kg of diet singly and in combination were characterized in male broiler chicks from 1 d to 3 wk of age. Body weights were depressed by T-2, CPA, and the combination of T-2 and CPA. There was a significant synergistic interaction between T-2 and CPA for relative liver and kidney weights and serum cholesterol and triglyceride concentrations and a significant interaction between T-2 and CPA for 3-wk body weights and relative bursa of Fabricius weights, which were less than additive. Neither the efficiency of feed utilization nor mortality was affected by dietary treatments. Oral lesions were present in a majority of the chicks fed diets containing T-2 with or without CPA. When compared with controls, other variables measured exhibited additive or less than additive toxicity. These data demonstrate that T-2 and CPA alone and in combination can cause reduced performance and adversely affect broiler health. The effects of these mycotoxins may be exacerbated by other factors when under field conditions; hence, the potential detrimental effects of these two mycotoxins when present alone or in combination cannot be dismissed.
研究了在1日龄至3周龄雄性肉鸡日粮中单独添加6毫克T-2毒素（T-2）和34毫克环匹阿尼酸（CPA）以及二者联合添加的影响。T-2、CPA以及T-2与CPA的组合均使体重降低。T-2与CPA在相对肝脏和肾脏重量、血清胆固醇和甘油三酯浓度方面存在显著的协同相互作用，在3周龄体重和法氏囊相对重量方面存在显著相互作用，其作用小于相加效应。日粮处理对饲料利用率和死亡率均无影响。大多数饲喂含T-2日粮（无论是否添加CPA）的雏鸡出现口腔病变。与对照组相比，所测定的其他变量表现出相加或小于相加的毒性。这些数据表明，T-2和CPA单独及联合使用均可导致生产性能下降并对肉鸡健康产生不利影响。在田间条件下，其他因素可能会加剧这些霉菌毒素的影响；因此，这两种霉菌毒素单独或联合存在时的潜在有害影响不容忽视。
