一项针对接触苯乙烯工人的历史性队列研究中的癌症死亡率。
Cancer mortality in a historical cohort study of workers exposed to styrene.
作者信息
Kogevinas M, Ferro G, Andersen A, Bellander T, Biocca M, Coggon D, Gennaro V, Hutchings S, Kolstad H, Lundberg I
机构信息
Unit of Analytical Epidemiology, International Agency for Research on Cancer, Lyon, France.
出版信息
Scand J Work Environ Health. 1994 Aug;20(4):251-61. doi: 10.5271/sjweh.1400.
OBJECTIVES
The goal of this study was to determine whether exposure to styrene is associated with an increased risk for neoplasms of the lymphatic and hematopoietic tissues.
METHODS
A historical cohort study was conducted in Denmark, Finland, Italy, Norway, Sweden, and the United Kingdom. It involved 40,688 workers ever employed in the reinforced plastics industry, where high exposure to styrene occurs. Exposure to styrene was reconstructed through job histories and environmental and biological monitoring data. Cause-specific national death rates were used as the reference. Poisson regression was applied for internal comparisons.
RESULTS
Among the exposed workers, no excess was observed for mortality from all neoplasms. Mortality from neoplasms of the lymphatic and hematopoietic tissues increased with time since first exposure and average level of exposure to styrene, but was not consistently associated with duration of exposure or with cumulative exposure.
CONCLUSIONS
These findings leave open the possibility of an excess risk of neoplasms of the lymphatic and hematopoietic tissues among workers exposed to styrene.
目的
本研究的目的是确定接触苯乙烯是否与淋巴和造血组织肿瘤风险增加有关。
方法
在丹麦、芬兰、意大利、挪威、瑞典和英国进行了一项历史性队列研究。研究对象为曾在强化塑料行业工作的40688名工人，该行业存在高浓度苯乙烯暴露。通过工作经历以及环境和生物监测数据来重建苯乙烯暴露情况。以特定病因的全国死亡率作为参照。采用泊松回归进行内部比较。
结果
在接触苯乙烯的工人中，未观察到所有肿瘤的死亡率有过剩情况。淋巴和造血组织肿瘤的死亡率随首次接触苯乙烯后的时间以及苯乙烯平均暴露水平的增加而上升，但与暴露持续时间或累积暴露量并无始终一致的关联。
结论
这些发现并未排除接触苯乙烯的工人患淋巴和造血组织肿瘤的风险可能增加这一可能性。
Zotero 插件