Dudarev A L, Korytova L I, Ilín N V
Vestn Rentgenol Radiol. 1993 Sep-Oct(5):43-5.
Total-system radiotherapy in the form of subtotae irradiation of the body was administered to 43 primary patients with stages IIB-IVB Hodgkin's disease as the first stage of antitumor treatment as an alternative to chemotherapy. An immediate stable antitumor effect was observed manifasting by intoxication arrest, reduction of the lymph nodes in size and of specific infiltration in the lungs, as well as by decrease of red cell sedimentation rate. The mean duration of the course was 10.6 days with a 35.0 days interval till the next stage. Regularities in the time course of hematologic parameters over the course of subtotal irradiation and after it were followed up. Remote (5-year) results of treatment of patients with Hodgkin's disease making use of subtotal irradiation of the body at the first stage of antitumor therapy compatible to those in controls were demonstrated for the first time.
对43例IIB-IVB期霍奇金病的初治患者，采用全身局部照射形式的全系统放疗作为抗肿瘤治疗的第一阶段，替代化疗。观察到立即出现稳定的抗肿瘤效果，表现为中毒症状停止、淋巴结大小缩小、肺部特异性浸润减轻以及红细胞沉降率降低。疗程平均持续10.6天，至下一阶段间隔35.0天。对局部照射过程中及照射后血液学参数的时间进程规律进行了跟踪。首次证明了在抗肿瘤治疗第一阶段采用全身局部照射的霍奇金病患者的远期（5年）治疗结果与对照组相当。
