足月自然分娩过程中，羊水前列腺素浓度早期会升高。
Amniotic fluid prostanoid concentrations increase early during the course of spontaneous labor at term.
作者信息
Romero R, Baumann P, Gonzalez R, Gomez R, Rittenhouse L, Behnke E, Mitchell M D
机构信息
Department of Obstetrics and Gynecology, Hutzel Hospital/Wayne State University, Detroit, MI 48201.
出版信息
Am J Obstet Gynecol. 1994 Dec;171(6):1613-20. doi: 10.1016/0002-9378(94)90412-x.
OBJECTIVE
The purpose of this study was to determine whether amniotic fluid concentrations of prostanoids increase during spontaneous labor at term.
STUDY DESIGN
Amniotic fluid was retrieved transabdominally from 168 patients in spontaneous labor and from 82 patients not in labor. Prostaglandin E2, prostaglandin F2 alpha, 13, 14-dihydro-15-keto-prostaglandin F2 alpha, thromboxane B2, and 6-keto-prostaglandin F1 alpha concentrations were measured with sensitive and specific radioimmunoassays previously validated for amniotic fluid. Statistical analysis was conducted with Kruskal-Wallis analysis of variance, followed by Dunn's test for multiple comparisons.
RESULTS
(1) Amniotic fluid concentrations of all prostanoids were significantly higher in patients in early labor (cervical dilatation of < or = 3 cm) than in patients not in labor. (2) The magnitude of the increase in amniotic fluid prostanoid concentrations during early labor was significantly greater for prostaglandin F2 alpha and 13,14-dihydro-15-keto-prostaglandin F2 alpha than for prostaglandin E2, thromboxane B2, and 6-keto-prostaglandin F1 alpha. (3) Patients in the active phase of labor with cervical dilatations between 4 and 7 cm did not have higher prostanoid concentrations than those in early labor (cervical dilatation of < or = 3 cm). (4) A significant increase in amniotic fluid concentrations of prostaglandin F2 alpha and 13,14-dihydro-15-keto-prostaglandin F2 alpha was found in patients with advanced cervical dilatation (8 to 10 cm) in comparison with those in early labor (< 3 cm).
CONCLUSION
Amniotic fluid prostanoid concentrations increase early during the course of spontaneous labor at term.
目的
本研究旨在确定足月自然分娩过程中羊水中前列腺素浓度是否会升高。
研究设计
经腹从168例自然分娩患者和82例未分娩患者获取羊水。采用先前已验证适用于羊水的灵敏且特异的放射免疫分析法测定前列腺素E2、前列腺素F2α、13,14-二氢-15-酮-前列腺素F2α、血栓素B2和6-酮-前列腺素F1α的浓度。采用Kruskal-Wallis方差分析进行统计分析，随后进行Dunn多重比较检验。
结果
（1）早期分娩（宫颈扩张≤3 cm）患者羊水中所有前列腺素的浓度显著高于未分娩患者。（2）早期分娩期间羊水中前列腺素浓度升高的幅度，前列腺素F2α和13,14-二氢-15-酮-前列腺素F2α显著大于前列腺素E2、血栓素B2和6-酮-前列腺素F1α。（3）宫颈扩张在4至7 cm的活跃期分娩患者，其前列腺素浓度并不高于早期分娩（宫颈扩张≤3 cm）患者。（4）与早期分娩（<3 cm）患者相比，宫颈扩张晚期（8至10 cm）患者羊水中前列腺素F2α和13,14-二氢-15-酮-前列腺素F2α浓度显著升高。
结论
足月自然分娩过程中羊水前列腺素浓度在早期升高。
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