Nikoda V V, Petrov R O, Sandrikov V A, Chizhov A I
Anesteziol Reanimatol. 1994 Jul-Aug(4):28-9.
Opioid analgesics buprenorphine, nubain, and morphine were used in 33 patients suffering from acute postoperative pain on days 1-3 after operations on the lungs, heart and main vessels, abdominal organs. Buprenorphine was used in dose 0.01 mg/kg, nubain in dose 0.3 mg/kg, and morphine in dose 0.3 mg/kg. Effects of opioid analgesics on O2 consumption, carbon dioxide exhalation, minute respiration volume, and total energy metabolism were monitored. Effects of buprenorphine on metabolism and ventilation were the most manifest: it lead to reduction of metabolism by 26.2% and minute respiration volume by 36%. Nubain had no noticeable effect on metabolism or ventilation parameters. Morphine lead to moderately expressed changes in metabolism and ventilation reducing metabolism by 12.5% and minute respiration volume by 10.3%.
阿片类镇痛药丁丙诺啡、纳布啡和吗啡用于33例在肺、心脏、主血管及腹部器官手术后1至3天遭受急性术后疼痛的患者。丁丙诺啡的使用剂量为0.01mg/kg，纳布啡为0.3mg/kg，吗啡为0.3mg/kg。监测了阿片类镇痛药对氧气消耗、二氧化碳呼出、分钟呼吸量和总能量代谢的影响。丁丙诺啡对代谢和通气的影响最为明显：它使代谢降低26.2%，分钟呼吸量降低36%。纳布啡对代谢或通气参数没有明显影响。吗啡导致代谢和通气出现中度明显变化，使代谢降低12.5%，分钟呼吸量降低10.3%。
