Nikoda V V, Sandrikov V A, Lebedeva R N, Vinnitskiĭ L I, Egorova I A, Petrov R O, Chizhov A I, Poroĭkova M V
Anesteziol Reanimatol. 1994 Mar-Apr(2):40-3.
Nubaine (N) was used in 92 patients operated on the lungs, heart and major vessels, abdominal organs. N at a dose of 0.3 mg/kg caused adequate analgesia in 62-85% of cases on days 1-3 after surgery; it is an effective analgesic among those used in patients with acute postoperative pain. The effect of N on circulation, respiration, gas exchange, metabolism, and hormonal status was studied. It has been shown that N is a safe agent which has no considerable effect on respiration, hemodynamics, blood gas composition, and metabolism. In patients at high risk analgesia with N caused no serious side effects.
纳布啡（N）用于92例接受肺部、心脏、大血管及腹部器官手术的患者。剂量为0.3mg/kg的纳布啡在术后第1 - 3天62% - 85%的病例中产生了充分的镇痛效果；在用于急性术后疼痛患者的药物中，它是一种有效的镇痛药。研究了纳布啡对循环、呼吸、气体交换、代谢及激素状态的影响。结果表明，纳布啡是一种安全的药物，对呼吸、血流动力学、血气成分及代谢无显著影响。在高危患者中，使用纳布啡进行镇痛未引起严重副作用。
