羟钴胺对某些生化参数测定干扰的相关机制研究。

Study of the mechanisms involved in hydroxocobalamin interference with determination of some biochemical parameters.

作者信息

Gourlain H, Caliez C, Laforge M, Buneaux F, Levillain P

机构信息

Laboratoire de Biochimie-Toxicologie, Hôpital Fernand-Widal, Paris, France.

出版信息

Ann Biol Clin (Paris). 1994;52(2):121-4.

PMID:7802338

Abstract

Hydroxocobalamin (OHCo), a red pigment used as an antidote in cyanide poisoning, interferes with determination of some biochemical parameters. Plasma pools were spiked with two concentrations of OHCo and eight parameters (CK, SGOT, SGPT, ALP, lactic acid, creatinine, glucose, bilirubin) were assayed using Dimension and Aca III automated analyzers (Du Pont Instruments). Two parameters were affected by the presence of OHCo: CK and bilirubin. This study documents the type of interferences, spectral or chemical, and its probable causes.

摘要

羟钴胺素（OHCo）是一种红色色素，用作氰化物中毒的解毒剂，它会干扰某些生化参数的测定。在血浆样本中加入两种浓度的OHCo，然后使用Dimension和Aca III自动分析仪（杜邦仪器）检测八个参数（肌酸激酶、谷草转氨酶、谷丙转氨酶、碱性磷酸酶、乳酸、肌酐、葡萄糖、胆红素）。有两个参数受到OHCo存在的影响：肌酸激酶和胆红素。本研究记录了干扰的类型，是光谱干扰还是化学干扰，以及其可能的原因。