Curry S C, Connor D A, Raschke R A
Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, Arizona.
Ann Emerg Med. 1994 Jul;24(1):65-7. doi: 10.1016/s0196-0644(94)70164-4.
Concentrated aqueous solutions of hydroxocobalamin (OHCob) are given intravenously for the treatment of cyanide poisoning. Because OHCob solutions are intensely red and have peak light absorptions at 352 nm and 525 nm, we investigated whether the presence of OHCob in serum would interfere with various automated, colorimetric chemistry measurements.
Selected serum chemistry colorimetric measurements were compared in seven patients, using their own serum as control, with serum containing OHCob at the following concentrations: 100 mg/L, 500 mg/L, and 1,000 mg/L. These concentrations are in the range achieved with therapeutic doses of OHCob when given for cyanide poisoning.
Statistically significant alterations in serum values for aspartate aminotransferase, total bilirubin, creatinine, magnesium, and iron were seen in the presence of OHCob.
The presence of OHCob in serum interferes with several chemistry methodologies, and such interference should be anticipated when this antidote is used.
静脉注射高浓度的羟钴胺（OHCob）水溶液用于治疗氰化物中毒。由于OHCob溶液呈深红色，且在352纳米和525纳米处有光吸收峰值，我们研究了血清中OHCob的存在是否会干扰各种自动化比色化学测量。
选取7名患者，以他们自身的血清作为对照，与含有以下浓度OHCob的血清进行比较，对选定的血清化学比色测量项目进行检测：100毫克/升、500毫克/升和1000毫克/升。这些浓度处于氰化物中毒时给予治疗剂量的OHCob所达到的范围。
在存在OHCob的情况下，观察到天冬氨酸转氨酶、总胆红素、肌酐、镁和铁的血清值有统计学意义的改变。
血清中OHCob的存在会干扰几种化学检测方法，使用这种解毒剂时应预料到这种干扰。
