Lin J L, Jeng L B
Division of Nephrology and Poison Center, Chang Gung Memorial Hospital, Lin-Kou Medical Center, Chang Gung Medical College, Taipei, Taiwan, Republic of China.
Ann Emerg Med. 1995 Jan;25(1):75-80. doi: 10.1016/s0196-0644(95)70359-4.
To investigate the efficiency of a new non-pump hemoperfusion technique, continuous arteriovenous hemoperfusion, in the treatment of critical, acutely poisoned patients.
Emergency department of a general hospital.
Acutely poisoned patients who failed to respond to intensive supportive treatment and needed hemoperfusion therapy.
All patients received continuous arteriovenous hemoperfusion therapy for 4 to 8 hours. Toxicant clearances were determined by obtaining serial theophylline and phenobarbital levels every 2 hours before, during, and after continuous arteriovenous hemoperfusion. Platelet counts, whole-blood activated clotting time, and vital signs were monitored.
The clinical condition of these patients improved rapidly after continuous arteriovenous hemoperfusion was started. The treatments were performed easily, and no significant complications occurred. The clearances of theophylline and phenobarbital were 192.79 +/- 1.55 mL/min and 290.25 +/- 25.33 mL/min, respectively, similar to those of conventional hemoperfusion.
Continuous arteriovenous hemoperfusion is a simple, safe, effective, and less costly alternative to conventional hemoperfusion, especially in the EDs of hospitals without hemoperfusion facilities immediately available.
探讨一种新的非泵血液灌流技术——持续动静脉血液灌流，在治疗重症急性中毒患者中的有效性。
一家综合医院的急诊科。
对强化支持治疗无反应且需要血液灌流治疗的急性中毒患者。
所有患者接受持续动静脉血液灌流治疗4至8小时。通过在持续动静脉血液灌流前、期间和之后每2小时获取系列茶碱和苯巴比妥水平来测定毒物清除率。监测血小板计数、全血活化凝血时间和生命体征。
开始持续动静脉血液灌流后，这些患者的临床状况迅速改善。治疗操作简便，未发生明显并发症。茶碱和苯巴比妥的清除率分别为192.79±1.55 mL/分钟和290.25±25.33 mL/分钟，与传统血液灌流相似。
持续动静脉血液灌流是一种简单、安全、有效的替代传统血液灌流的方法，成本更低，尤其适用于没有即时可用血液灌流设备的医院急诊科。
