Lin J L, Lim P S
Division of Nephrology and Poison Center, Chang Gung Memorial Hospital, Chang Gung Medical College, Lin-Kou Medical Center, Taipei, Taiwan, ROC.
Blood Purif. 1994;12(2):121-7. doi: 10.1159/000170156.
We have investigated the efficacy of a pumpless hemoperfusion technique, continuous arteriovenous hemoperfusion (CAVHP) in 3 cases of acute intoxications with meprobamate, theophylline and phenobarbital. Dramatic responses were noted in both hemodynamic unstable and comatous patients. With this technique, a blood flow of 120 cm3/min could be achieved in severe hypotension. Moreover, with the restoration of blood pressure, blood flow increased to 150-400 cm3/min. Our preliminary experience has shown that CAVHP allows an exceptionally high solute elimination. Hemoperfusion clearances of meprobamate, phenobarbital and theophylline were 198 +/- 5.6 cm3/min, 290.25 +/- 25.33 cm3/min and 192.79 +/- 55 cm3/min, respectively. Our present results suggest that CAVHP is a simple, safe, effective and less costly alterative of conventional hemoperfusion.
我们研究了一种无泵血液灌流技术——持续动静脉血液灌流（CAVHP）在3例服用眠尔通、茶碱和苯巴比妥急性中毒患者中的疗效。在血流动力学不稳定和昏迷患者中均观察到显著反应。采用该技术，在严重低血压情况下可实现120立方厘米/分钟的血流量。此外，随着血压恢复，血流量增加至150 - 400立方厘米/分钟。我们的初步经验表明，CAVHP能实现极高的溶质清除率。眠尔通、苯巴比妥和茶碱的血液灌流清除率分别为198±5.6立方厘米/分钟、290.25±25.33立方厘米/分钟和192.79±55立方厘米/分钟。我们目前的结果表明，CAVHP是一种简单、安全、有效且成本较低的传统血液灌流替代方法。
