Kirby R E, Lewandrowski K B, Southern J F, Compton C C, Warshaw A L
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston.
Arch Surg. 1995 Jan;130(1):69-72. doi: 10.1001/archsurg.1995.01430010071014.
To evaluate the role of epidermal growth factor receptor (EGF-R) and pS2 protein in the evolution of malignancy in mucinous cystic tumors of the pancreas.
Mucinous cystic tumors of the pancreas include histologically benign but premalignant mucinous cystic neoplasms and mucinous cystadenocarcinoma. The molecular events leading to transformation from a benign to a malignant mucinous tumor are not known. Overexpression of EGF-R and detection of an estrogen-induced protein (pS2) has been demonstrated in ductal adenocarcinomas of the pancreas, but these factors have not been evaluated in mucinous cystic tumors.
Twenty-six mucinous tumors were examined for EGF-R, pS2 protein, and estrogen and progesterone receptors.
Eight (61.2%) of 13 malignant tumors exhibited increased expression of EGF-R, whereas EGF-R was not detected in any of the 13 benign tumors (P = .002). The pS2 protein was detected in nine of 11 malignant and 11 of 11 benign tumors (P = .480). Estrogen and progesterone receptors were not detected in the epithelium of either tumor type. The median survival time of the patients with EGF-R-negative tumors was 29.0 months compared with 14.5 months for those with EGF-R-positive tumors, but this difference did not reach significance owing to the small population size.
Overexpression of EGF-R in mucinous cystic tumors, as in ductal adenocarcinomas, may be an important feature associated with malignancy and may have prognostic significance. Failure to detect EGF-R in histologically benign epithelium suggests that the upregulation of EGF-R may be important in the evolution of aggressive behavior. The expression of pS2 protein appears to be independent of estrogen and may play a role in the proliferative activity of mucinous tumors. However, pS2 expression is not a feature associated exclusively with malignancy.
评估表皮生长因子受体（EGF-R）和pS2蛋白在胰腺黏液性囊性肿瘤恶变过程中的作用。
胰腺黏液性囊性肿瘤包括组织学上良性但具有恶变倾向的黏液性囊性肿瘤和黏液性囊腺癌。导致良性黏液性肿瘤转变为恶性肿瘤的分子事件尚不清楚。胰腺导管腺癌中已证实存在EGF-R的过表达及雌激素诱导蛋白（pS2）的检测，但这些因素在黏液性囊性肿瘤中尚未得到评估。
对26例黏液性肿瘤进行EGF-R、pS2蛋白以及雌激素和孕激素受体检测。
13例恶性肿瘤中有8例（61.2%）表现出EGF-R表达增加，而13例良性肿瘤中均未检测到EGF-R（P = 0.002）。11例恶性肿瘤中有9例检测到pS2蛋白，11例良性肿瘤中也有11例检测到pS2蛋白（P = 0.480）。两种肿瘤类型的上皮细胞中均未检测到雌激素和孕激素受体。EGF-R阴性肿瘤患者的中位生存时间为29.0个月，而EGF-R阳性肿瘤患者为14.5个月，但由于样本量小，这种差异未达到统计学意义。
与导管腺癌一样，黏液性囊性肿瘤中EGF-R的过表达可能是与恶性肿瘤相关的重要特征，且可能具有预后意义。在组织学上良性的上皮细胞中未检测到EGF-R，提示EGF-R的上调可能在侵袭性行为的演变中起重要作用。pS2蛋白的表达似乎与雌激素无关，可能在黏液性肿瘤的增殖活性中起作用。然而，pS2表达并非恶性肿瘤所特有的特征。
