Sillar K T, Simmers A J
Gatty Marine Laboratory, School of Biological & Medical Sciences, University of St. Andrews, Scotland.
Eur J Morphol. 1994 Aug;32(2-4):293-8.
In the presence of TTX and NMDA, spinal cord neurons in Rana temporaria embryos generate membrane potential oscillations, but only when 5-HT is added to the perfusate. These oscillations are voltage-dependent due to magnesium block of the NMDA receptor ionophore and can vary in amplitude between 0 and 40 mV with imposed membrane polarization. In contrast, the intrinsic frequency of the oscillations is unaffected by changes in membrane potential. This could result from electrical coupling amongst homonymous motoneurons. Here we present initial evidence for such connections and discuss their implications for the segmental control of rhythmic motor behaviour.
在存在河豚毒素（TTX）和N-甲基-D-天冬氨酸（NMDA）的情况下，林蛙胚胎的脊髓神经元会产生膜电位振荡，但只有在向灌注液中添加5-羟色胺（5-HT）时才会出现这种情况。由于NMDA受体离子通道被镁离子阻断，这些振荡是电压依赖性的，并且在施加膜极化时，其振幅可在0至40毫伏之间变化。相比之下，振荡的固有频率不受膜电位变化的影响。这可能是由同名运动神经元之间的电耦合导致的。在此，我们展示了此类连接的初步证据，并讨论了它们对节律性运动行为的节段性控制的影响。
