Vlasveld L T, Splinter T A, Hagemeijer A, Van Lom K, Löwenberg B
Department of Haematology, Erasmus University, Rotterdam, The Netherlands.
Br J Haematol. 1994 Sep;88(1):196-8. doi: 10.1111/j.1365-2141.1994.tb04997.x.
We report a patient who developed acute myeloid leukaemia (M2) shortly after successful treatment of a mediastinal germ cell tumour. The leukaemia was preceded by a documented myelodysplastic phase. Complex cytogenetic abnormalities were found in bone marrow and peripheral blood cells including +i(12p), typical of germ cell malignancy. Fluorescence in situ hybridization revealed the presence of +i(12p) in myeloblasts, erythroblasts and neutrophils but not in lymphocytes. This case provides further evidence for a common clonal origin of haematological malignancies and mediastinal germ cell tumours.
我们报告了一名患者，该患者在纵隔生殖细胞肿瘤成功治疗后不久发生了急性髓系白血病（M2）。白血病之前有一段记录在案的骨髓增生异常阶段。在骨髓和外周血细胞中发现了复杂的细胞遗传学异常，包括+i(12p)，这是生殖细胞恶性肿瘤的典型特征。荧光原位杂交显示，原粒细胞、幼红细胞和中性粒细胞中存在+i(12p)，而淋巴细胞中不存在。该病例为血液系统恶性肿瘤和纵隔生殖细胞肿瘤的共同克隆起源提供了进一步证据。
