Bladé J, Kyle R A
Postgraduate School of Haematology, Farreras-Valenti Hospital Clinic i Provincial, Barcelona, Spain.
Br J Haematol. 1994 Oct;88(2):395-6. doi: 10.1111/j.1365-2141.1994.tb05037.x.
The presence of a serum IgD monoclonal protein (M-protein) is usually indicative of a malignant plasma cell disorder. However, one case of well-documented benign monoclonal gammopathy (BMG) of IgD type has been reported. We describe another patient with IgD monoclonal gammopathy of undetermined significance (MGUS) with long-term follow-up. In this patient an IgD lambda M-protein was found on routine serum electrophoresis. She is alive and has no evidence of multiple myeloma or amyloidosis after 8 years of follow-up. Although IgD MGUS is exceedingly rare, this case demonstrates that the presence of a serum IgD M-protein is not necessarily synonymous with a malignant plasma cell process.
血清IgD单克隆蛋白（M蛋白）的存在通常提示恶性浆细胞疾病。然而，曾有一例记录完备的IgD型良性单克隆丙种球蛋白病（BMG）的报道。我们描述了另一例具有长期随访结果的意义未明的IgD单克隆丙种球蛋白病（MGUS）患者。该患者在常规血清电泳中发现了IgD λ M蛋白。经过8年的随访，她仍然存活，且没有多发性骨髓瘤或淀粉样变性的证据。虽然IgD MGUS极为罕见，但该病例表明血清IgD M蛋白的存在并不一定等同于恶性浆细胞病变。
