Kinoshita T, Nagai H, Murate T, Saito H, Fukatsu T, Hotta T
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Int J Hematol. 1997 Feb;65(2):169-72. doi: 10.1016/s0925-5710(96)00557-9.
We describe here a case of monoclonal gammopathy of undetermined significance (MGUS) of IgD type. A trace of serum M-protein was noticed on electrophoresis when a Japanese man visited his primary care physician for medical examination. However, he was asymptomatic. Serum immunoelectrophoresis showed IgD lambda M-protein. Bone marrow examination revealed normocellular marrow with 1.5% plasma cells. Renal function, serum calcium level and complete blood cell count were all within normal limits and a systemic bone survey disclosed no lytic lesions. He was followed for 26 months without chemotherapy, and no disease progression to overt myeloma nor development of systemic amyloidosis resulted. This is, to our knowledge, the third case of IgD MGUS and the first one reported from Japan.
我们在此描述一例IgD型意义未明的单克隆丙种球蛋白病（MGUS）。一名日本男性因体检前往其初级保健医生处就诊时，电泳发现微量血清M蛋白。然而，他并无症状。血清免疫电泳显示为IgD λ M蛋白。骨髓检查显示骨髓细胞正常，浆细胞占1.5%。肾功能、血清钙水平及全血细胞计数均在正常范围内，全身骨骼检查未发现溶骨性病变。他在未接受化疗的情况下随访了26个月，未出现疾病进展为明显骨髓瘤或全身性淀粉样变性。据我们所知，这是第三例IgD MGUS病例，也是日本报道的首例。
