Moldofsky H
University of Toronto Centre for Sleep and Chronobiology, Ontario.
J Psychiatry Neurosci. 1994 Nov;19(5):368-74.
This paper reviews the relationship of aspects of the immune system to the sleep-wake system in animals and humans. In addition to the influence of certain cytokines such as interleukin-1 (IL-1) on the sleeping-waking brain, circadian measures of plasma IL-1 and peripheral immune cellular functions, for example, natural killer cell activities and cortisol are related to the sleep-wake system in humans. Changes in the circadian patterns of immune functions over the menstrual cycle are associated with the amount of progesterone and slow wave sleep. The harmonious inter-relationship of the circadian pattern of the immune, endocrine and sleep-wake systems may be important in the cause and functions of sleep.
本文综述了动物和人类免疫系统各方面与睡眠-觉醒系统之间的关系。除了某些细胞因子(如白细胞介素-1,IL-1)对睡眠-觉醒大脑的影响外,血浆IL-1的昼夜节律指标以及外周免疫细胞功能(例如自然杀伤细胞活性和皮质醇)与人类的睡眠-觉醒系统有关。月经周期中免疫功能昼夜节律模式的变化与孕酮水平和慢波睡眠量有关。免疫、内分泌和睡眠-觉醒系统昼夜节律模式的和谐相互关系可能在睡眠的成因和功能中起重要作用。