Sulbarán T, Aparicio J, Bermúdez G
Centro de Enfermedades Cardiovasculares, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
Invest Clin. 1994 Sep;35(3):143-54.
The purpose of this study was to evaluate the antihypertensive efficacy of captopril (C) and its correlation with body mass index (BMI), age and initial blood pressure (BP) in hypertensive crises. The time of the beginning of the antihypertensive effect of C and its side effects were evaluated. Twenty patients, aged between 22 and 59 years, were included in this investigation. BP was measured after 15 min of rest; age, weight and height were recorded and BMI was calculated using the standard formula (Kg/m2). Patients were not taking antihypertensive medications. After the placebo was given to the patients, BP was measured at 30 and 60 min. Sublingual captopril 25 mg was administered and BP was again measured at 5, 10, 15, 30, 60, 120 y 240 min. There was not statistically significant difference between the values of BP before and after placebo. A significant decrease was observed post C, from 182.6/123.6 to 174.6/117.3 (p:SN/p < 0.02) in 10 min., to 169.9/114.9 (p < 0.04/p < 0.001) in 15 min., to 167.7/112.2 (p < 0.02/p < 0.0001) in 30 min., to 164.3/108.8 (p < 0.002/p < 0.0001) in 60 min., to 156.9/106.5 (p < 0.0001/p < 0.0001) in 120 min., to 161.3/107.0 (p < 0.0002/p < 0.0001) in 240 min. In 15 patients there was a decrease in diastolic BP > or = 5 mmHg, 10 min. post C. No correlation was found between decrease in BP and age, nor with BMI. Pearson r correlation index between the decrease in systolic BP and initial systolic BP was 0.63 (p < 0.003) and between the decrease in diastolic BP and initial diastolic BP, 0.59 (p < 0.005). Secondary effects were mild and well tolerated. In conclusion, C effectively reduced BP in hypertensive crises. Because the efficacy of C, its rapid onset of action and minimal side effects, sublingual Captopril should be considered a first line drug for hypertensive crises.
本研究旨在评估卡托普利（C）在高血压危象中的降压疗效及其与体重指数（BMI）、年龄和初始血压（BP）的相关性。评估了C降压作用开始的时间及其副作用。本研究纳入了20例年龄在22至59岁之间的患者。休息15分钟后测量血压；记录年龄、体重和身高，并使用标准公式（千克/平方米）计算BMI。患者未服用抗高血压药物。给患者服用安慰剂后，在30分钟和60分钟时测量血压。舌下含服25毫克卡托普利，然后在5、10、15、30、60、120和240分钟时再次测量血压。安慰剂前后的血压值之间无统计学显著差异。服用C后观察到显著下降，10分钟时从182.6/123.6降至174.6/117.3（p:SN/p < 0.02），15分钟时降至169.9/114.9（p < 0.04/p < 0.001），30分钟时降至167.7/112.2（p < 0.
