Alletto M, Burgio A, Fulco G, Paradiso R, Piangiamore M, Vancheri F
II Divisione di Medicina interna, Ospedale Castelnuovo, USL 16, Caltanissetta.
Recenti Prog Med. 1992 Sep;83(9):503-5.
Captopril is widely used in severe hypertension. Oral administration takes one-two hours to achieve a maximum effect and is not useful in hypertensive crisis. Few reports describe a more rapid effect on blood pressure following sublingual administration. We evaluated the effect of sublingual captopril 50 mg, in 26 patients with hypertensive crisis. Blood pressure levels started to decrease within 10 minutes and the maximum effect was observed 30 minutes after administration of the tablet. In all patients mean (CI 95%) systolic blood pressure dropped from 202.5 (199-206) mmHg to 160.6 (156-165) mmHg and diastolic blood pressure from 105.6 (102-109) mmHg to 86.9 (83-7-90.1) mmHg. This effect was maintained over two hours. There were no side effects. Sublingual captopril is highly effective in hypertensive crisis and its gradual hypotensive action avoid dangerous abrupt fall in blood pressure.
卡托普利广泛应用于重度高血压。口服给药需1至2小时达到最大效果，对高血压危象无效。很少有报告描述舌下给药后对血压有更快的效果。我们评估了50毫克舌下含服卡托普利对26例高血压危象患者的效果。血压水平在10分钟内开始下降，给药后30分钟观察到最大效果。所有患者的平均（95%置信区间）收缩压从202.5（199 - 206）毫米汞柱降至160.6（156 - 165）毫米汞柱，舒张压从105.6（102 - 109）毫米汞柱降至86.9（83 - 90.1）毫米汞柱。这种效果持续了两个多小时。未出现副作用。舌下含服卡托普利在高血压危象中非常有效，其逐渐的降压作用可避免血压危险的急剧下降。
