Parry B L, Hauger R, Lin E, Le Veau B, Mostofi N, Clopton P L, Gillin J C
Department of Psychiatry, University of California, San Diego 92093-0804.
Biol Psychiatry. 1994 Sep 15;36(6):356-64. doi: 10.1016/0006-3223(94)91210-6.
In 20 late luteal phase dysphoric disorder (LLPDD) and in 11 normal control (NC) subjects, circadian profiles of cortisol, prolactin, thyrotropin-stimulating hormone (TSH), and core body temperature were measured during midfollicular (MF) and late luteal (LL) menstrual cycle phases and after 1 week of light therapy either with (1) bright (tau 2500 lux) white morning (6:30 AM to 8:30 AM), (2) bright white evening (7 PM to 9 PM) or (3) dim (< 10 lux) red evening light, randomly administered in three separate luteal phases. In NC but not PMDD subjects, the cortisol peak significantly delayed in the LL compared with the MF phase. In PMDD, prolactin peak and amplitude were higher, prolactin acrophase earlier, and temperature amplitude higher during both the MF and LL phases. After light treatment, prolactin amplitude remained higher in LLPDD than in controls. In both groups, bright light shifted the cortisol acrophase, and AM light increased the prolactin nadir. Bright PM light increased the TSH nadir in LLPDD, but decreased it in controls. Thus, menstrual cycle phase, diagnosis, and light therapy may differentially affect neuroendocrine systems.
在20名晚黄体期烦躁障碍（LLPDD）患者和11名正常对照（NC）受试者中，于卵泡中期（MF）和晚黄体期（LL）月经周期阶段以及在接受为期1周的光疗后，测量了皮质醇、催乳素、促甲状腺激素（TSH）和核心体温的昼夜节律变化。光疗分为三种情况，随机在三个不同的黄体期进行：（1）明亮（2500勒克斯）的白色早晨光（上午6:30至8:30）；（2）明亮的白色傍晚光（晚上7点至9点）；（3）昏暗（<10勒克斯）的红色傍晚光。与MF期相比，NC组而非经前烦躁障碍（PMDD）组的LL期皮质醇峰值显著延迟。在PMDD组中，MF期和LL期的催乳素峰值和幅度更高，催乳素相位更早，体温幅度更高。光疗后，LLPDD组的催乳素幅度仍高于对照组。在两组中，明亮光线均使皮质醇相位发生偏移，早晨光增加了催乳素的最低点。明亮的傍晚光增加了LLPDD组的TSH最低点，但在对照组中却使其降低。因此，月经周期阶段、诊断和光疗可能对神经内分泌系统产生不同的影响。
