180名女性乳腺癌患者一级亲属中的乳腺癌情况

Breast cancer in first degree relatives of 180 female breast cancer patients.

作者信息

Fürstenberger G, Christen H, Minder C E, Spycher M, Weber W

机构信息

Computing Department, University of Basel, Switzerland.

出版信息

In Vivo. 1994 May-Jun;8(3):367-70.

PMID:7803720

Abstract

The risk of breast cancer and of all malignancies was assessed in first degree relatives of 180 women with breast cancer using a historical cohort study approach. The standardized incidence ratio (SIR) was significantly (p < 0.05) increased for breast cancer in mothers: 1.97 (95% Confidence Interval (CI): 1.27 to 2.91) and in all female first degree relatives: 1.55 (95% CI: 1.08 to 2.15). For breast cancer in sisters it was 1.12 (95% CI: 0.56 to 2.01). For all malignancies the SIR for mothers was 1.12 (95% CI: 0.85 to 1.44), for sisters 1.09 (95% CI: 0.77 to 1.49) and for all female first degree relatives 1.08 (95% CI: 0.89 to 1.32). This study confirms previous investigations showing that breast cancer occurs more frequently in female first degree relatives of women with breast cancer than in the general population.

摘要

采用历史性队列研究方法，对180例乳腺癌女性患者的一级亲属患乳腺癌及所有恶性肿瘤的风险进行了评估。母亲患乳腺癌的标准化发病比（SIR）显著升高（p < 0.05）：为1.97（95%置信区间（CI）：1.27至2.91），所有女性一级亲属患乳腺癌的标准化发病比为1.55（95% CI：1.08至2.15）。姐妹患乳腺癌的标准化发病比为1.12（95% CI：0.56至2.01）。所有恶性肿瘤中，母亲的标准化发病比为1.12（95% CI：0.85至1.44），姐妹为1.09（95% CI：0.77至1.49），所有女性一级亲属为1.08（95% CI：0.89至1.32）。本研究证实了先前的调查结果，即乳腺癌女性患者的女性一级亲属患乳腺癌的频率高于一般人群。