Moutier R, Toyama K, Cotton W R, Gaines J F
J Hered. 1976 May-Jun;67(3):189-90. doi: 10.1093/oxfordjournals.jhered.a108705.
In the rat, the autosomal recessive toothless (t1) mutation exhibits an acute form of osteopetrosis. This gene is not an allele of either ia or op that causes respectively, a transitory and acute form of the disease. Comparative radiographic study of t1/t1 and op/op mutants reveals some differences in respect to the size and shape of long bones. In contrast to op/op mutants, homozygous t1/t1 animals failed to respond to either parabiosis or bone marrow transplants.
在大鼠中，常染色体隐性无牙（t1）突变表现出一种急性骨硬化症。该基因既不是导致暂时性和急性骨硬化症的ia基因，也不是op基因的等位基因。对t1/t1和op/op突变体的比较放射学研究显示，在长骨的大小和形状方面存在一些差异。与op/op突变体不同，纯合的t1/t1动物对联体生活或骨髓移植均无反应。
