Lee A K, Hester R B, Coggin J H, Gottlieb S F
Department of Biological Sciences, University of South Alabama, Mobile 36608.
Cancer Biother. 1993 Fall;8(3):241-52. doi: 10.1089/cbr.1993.8.241.
In acute and chronic experiments, each of eight groups of young mice were assigned separately to different pressures of oxygen to which it was to be exposed. Lymphocytes from spleen, thymus, and peripheral blood were analyzed following oxygen exposure. Subset populations changed depending on the oxygen tension. Blood lymphocyte populations reflected lymphocyte changes in thymus or spleen. Thus, a full understanding of the pharmacological effects of hyperbaric oxygen, requires a knowledge of simultaneous effects of increased oxygen pressures on the various compartments comprising the immune system.
在急性和慢性实验中，八组幼鼠被分别置于不同压力的氧气环境中。氧气暴露后，对脾脏、胸腺和外周血中的淋巴细胞进行分析。亚群数量随氧张力而变化。血液淋巴细胞数量反映了胸腺或脾脏中淋巴细胞的变化。因此，要全面了解高压氧的药理作用，需要了解氧气压力增加对构成免疫系统的各个部分的同时作用。
