Lee A K, Hester R B, Coggin J H, Gottlieb S F
Department of Biological Sciences, University of South Alabama, Mobile 36608.
Cancer Biother. 1994 Spring;9(1):39-54. doi: 10.1089/cbr.1994.9.39.
In acute and chronic experiments, each of eight groups of aged mice were assigned separately to different pressures of oxygen to which it was to be exposed. Lymphocytes from spleen, thymus, and peripheral blood were analyzed following oxygen exposure. Subset populations changed depending on the oxygen tension. Variable changes were observed in total numbers of lymphocytes, lymphocyte subsets, B cells, and macrophages depending on the organ studied and the oxygen pressure to which the mice were exposed. There were differences between acute and chronic exposure suggestive of adaptation to environmental stressors. The suggestion is made that the immune system has a reserve capacity that can be influenced by oxygen and, thereby, theoretically capable of being pharmacologically manipulated to assist patients with altered immune systems to promote defense mechanisms or, under certain circumstances, reduce autoimmunity. It is hypothesized that an underlying hypoxia may be involved in the age-associated decline in the immune system.
在急性和慢性实验中，八组老年小鼠分别被置于不同压力的氧气环境中。在氧气暴露后，对来自脾脏、胸腺和外周血的淋巴细胞进行分析。亚群数量根据氧张力而变化。根据所研究的器官以及小鼠所暴露的氧气压力，淋巴细胞总数、淋巴细胞亚群、B细胞和巨噬细胞的数量发生了不同变化。急性暴露和慢性暴露之间存在差异，提示对环境应激源的适应。有人提出，免疫系统具有储备能力，可受氧气影响，因此理论上能够通过药物手段进行调控，以帮助免疫系统改变的患者增强防御机制，或在某些情况下减少自身免疫。据推测，潜在的缺氧可能与免疫系统随年龄增长而衰退有关。
