Ochoa J L
Good Samaritan Hospital and Medical Center, Portland, Oregon.
Curr Opin Neurol. 1994 Oct;7(5):407-14. doi: 10.1097/00019052-199410000-00008.
Current opinion on "neuropathic" pain is chaotic and divided. This review is a summary attempt at describing the principal hypotheses that are currently entertained and at interpreting the basic underlying mechanisms of these pains. Rather than relying preferentially on rigorous data generated from neurophysiological animal experimentation, reasonable priority is given to evidence derived from rigorous neurophysiological and psychophysical studies in human volunteers and patients. Issues such as the concept of "centralization" of neuropathic pain mechanisms, which dwell excessively upon extrapolation from animal experiment to human clinical reality, are highlighted as questionable. Psychogenic pseudoneuropathy, an entity of high clinical prevalence and low appreciation by basic scientists and the reflex sympathetic dystrophy establishment, is also given the emphasis it deserves.
目前对于“神经性”疼痛的观点混乱且存在分歧。本综述旨在总结当前主要的假说，并阐释这些疼痛的基本潜在机制。相较于优先依赖神经生理学动物实验得出的严谨数据，合理地更重视来自人类志愿者和患者的严谨神经生理学及心理物理学研究的证据。诸如神经性疼痛机制“中枢化”概念等过度依赖从动物实验推断至人类临床实际的问题，被视为存在疑问而加以强调。心理性假性神经病变这一在临床中普遍存在但基础科学家和反射性交感神经营养不良领域认识不足的实体，也得到了应有的重视。
