Tooyama I, McGeer E G, Kawamata T, Kimura H, McGeer P L
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada.
Brain Res. 1994 Sep 5;656(1):165-8. doi: 10.1016/0006-8993(94)91378-1.
A count of pigmented neurons per mm3 in sections of the substantia nigra at the level where the oculomotor nerve emerges in 11 neurologically normal controls aged 15-82 showed the expected slow loss of such neurons with age. Most (82 +/- 3.8%) of the pigmented neurons showed immunoreactivity for basic fibroblast growth factor (bFGF) and this percentage was unaffected by age. This is in marked contrast to the case in Parkinson's disease where only some 12.7 +/- 2.6% of the remaining dopaminergic neurons showed bFGF-like immunoreactivity, providing further evidence against the hypothesis that Parkinson's disease is due to some early insult followed by age-related attrition of the remaining neurons.
在11名年龄在15 - 82岁的神经功能正常的对照者中，对动眼神经发出水平的黑质切片每立方毫米的色素神经元进行计数，结果显示此类神经元数量随年龄增长出现预期的缓慢减少。大多数（82±3.8%）色素神经元对碱性成纤维细胞生长因子（bFGF）呈免疫反应性，且这一百分比不受年龄影响。这与帕金森病的情况形成显著对比，在帕金森病中，仅约12.7±2.6%的剩余多巴胺能神经元呈bFGF样免疫反应性，这进一步证明了帕金森病并非由早期损伤后剩余神经元的年龄相关性损耗所致这一假说不成立。
