口腔微生物群失调与神经退行性疾病：相关性及潜在病因

Nicholson Justine S, Landry Kyle S

Delavie Sciences, Worcester, MA 01605, USA.

Department of Neurobiology, Columbia University, New York, NY 10027, USA.

Microorganisms. 2022 Jun 30;10(7):1326. doi: 10.3390/microorganisms10071326.

Biofilms are a heterogenous complex community of vegetative cells and extracellular polymeric substances that can adhere to various surfaces and are responsible for a variety of chronic and acute diseases. The impact of bacterial biofilms on oral and intestinal health is well studied, but the correlation and causations of biofilms and neurodegenerative diseases are still in their infancy. However, the correlations between biofilms and diseases such as Alzheimer's Disease, Multiple Sclerosis, and even Parkinson's Disease are starting to demonstrate the role bacterial biofilms have in promoting and exasperating various illnesses. The review article provides insight into the role bacterial biofilms may have on the development and progression of various neurodegenerative diseases and hopefully shine a light on this very important area of research.

生物膜是由营养细胞和细胞外聚合物组成的异质复杂群落，可附着于各种表面，并引发多种急慢性疾病。细菌生物膜对口腔和肠道健康的影响已得到充分研究，但生物膜与神经退行性疾病之间的相关性和因果关系仍处于起步阶段。然而，生物膜与阿尔茨海默病、多发性硬化症甚至帕金森病等疾病之间的相关性，正开始揭示细菌生物膜在引发和加剧各种疾病中所起的作用。这篇综述文章深入探讨了细菌生物膜在各种神经退行性疾病的发生和发展中可能扮演的角色，有望为这一非常重要的研究领域带来启示。