Mautino M R
Departamento de Química Biológica (CIQUIBIC-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Comput Appl Biosci. 1994 Jul;10(4):449-52. doi: 10.1093/bioinformatics/10.4.449.
The computer program COSMAP for construction of circular restriction maps has been developed. The generator is based on a permutational algorithm that puts forward all the possible maps that can be made with two enzymes, and the consistency checker compares the calculated and experimental double-digest fragment sizes within a predefined error bound. The output consists of the complete set of solutions ordered by a score number that is based on the matching degree between experimental and calculated double restriction fragment sizes. The program allows the application of heuristic rules which reduces the number of permutations to be checked and the number of sound solutions.
已经开发出用于构建环状限制图谱的计算机程序COSMAP。该生成器基于一种排列算法，该算法提出了用两种酶可以构建的所有可能图谱，一致性检查器在预定义的误差范围内比较计算的和实验的双酶切片段大小。输出结果是按分数排序的完整解集，该分数基于实验和计算的双限制片段大小之间的匹配程度。该程序允许应用启发式规则，这减少了要检查的排列数量和合理解决方案的数量。
