Yu S Z, Xu X H, Zhang J Q
Department of Neuropathology, Neurology Institute, Tianjin Medical College Hospital.
Zhonghua Bing Li Xue Za Zhi. 1994 Aug;23(4):221-3.
Fourty-four primary brain tumors were studied by immunohistochemistry. 29 (67.2%) expressed HLA-Dr. The incidence and number of tumor cells positive for HLA-Dr correlated with the histological type of brain tumor and increased with the degree of malignancy. The mononuclear cells infiltrating in these tumors were mostly CD45ROT cells and macrophages. The former consisted mainly of CD4 and CD8 subsets. The numbers of CD45RO+ and CD8+ T cells in HLA-Dr-group were more than any of the HLA-Dr+, +2, +3 groups. The numbers of CD4 subset and macrophages were not affected by the level of HLA-Dr expression. These results suggest that the HLA-Dr expressed by brain tumor cells selectively inhibit CD8 subset which participates in immunoreaction against brain tumors in situ.
通过免疫组织化学对44例原发性脑肿瘤进行了研究。29例（67.2%）表达HLA-Dr。HLA-Dr阳性肿瘤细胞的发生率和数量与脑肿瘤的组织学类型相关，并随恶性程度的增加而增加。浸润这些肿瘤的单核细胞主要是CD45ROT细胞和巨噬细胞。前者主要由CD4和CD8亚群组成。HLA-Dr阴性组中CD45RO+和CD8+T细胞的数量多于HLA-Dr阳性、+2、+3组中的任何一组。CD4亚群和巨噬细胞的数量不受HLA-Dr表达水平的影响。这些结果表明，脑肿瘤细胞表达的HLA-Dr选择性抑制参与原位抗脑肿瘤免疫反应的CD8亚群。
