Rossi M L, Esiri M M, Jones N R, Coakham H B, Moss T H, Cruz-Sanchez F F, Carey M P
Department of Neuropathology, Midland Centre for Neurology & Neurosurgery, Birmingham, Radcliffe Infirmary, Oxford, United Kingdom.
Surg Neurol. 1991 Aug;36(2):119-25. doi: 10.1016/0090-3019(91)90229-3.
We have studied frozen tissue from 19 oligodendrogliomas with a panel of antibodies to lymphocytes and their subsets, macrophages, natural killer cells, and HLA-Dr antigens. Macrophages were detected in moderate numbers in 60%-100% of tumors depending on the antibody used. T lymphocytes were fewer in number than macrophages and were present in 62% of cases. Most of the T lymphocytes were of the CD8 phenotype. CD4 lymphocytes were very few in number and present in only 18%. B cells and natural killer cells were absent from all cases. HLA-Dr antigens were expressed by macrophages in all cases but never on tumor cells. The implications of these findings are that macrophages and, to a lesser extent, CD8 lymphocytes are the predominant cells infiltrating oligodendrogliomas and that they may exert cellular immune functions.
我们使用一组针对淋巴细胞及其亚群、巨噬细胞、自然杀伤细胞和HLA - Dr抗原的抗体，对19例少突胶质细胞瘤的冷冻组织进行了研究。根据所使用的抗体不同，在60% - 100%的肿瘤中检测到数量适中的巨噬细胞。T淋巴细胞数量少于巨噬细胞，在62%的病例中存在。大多数T淋巴细胞为CD8表型。CD4淋巴细胞数量极少，仅在18%的病例中出现。所有病例均未发现B细胞和自然杀伤细胞。在所有病例中，巨噬细胞均表达HLA - Dr抗原，但肿瘤细胞从未表达。这些发现的意义在于，巨噬细胞以及在较小程度上的CD8淋巴细胞是浸润少突胶质细胞瘤的主要细胞，并且它们可能发挥细胞免疫功能。
