Worsley D F, Alavi A, Kim E, Palevsky H I
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
Clin Nucl Med. 1994 Oct;19(10):901-3. doi: 10.1097/00003072-199410000-00014.
Alveolar hypoxia is known to result in localized pulmonary arterial vasoconstriction. As a consequence, blood is diverted from poorly ventilated alveoli, maintaining ventilation-perfusion (V/Q) matching and thereby reducing the deleterious effects on gas exchange. An incomplete alveolar hypoxic vasoconstrictive response can be easily demonstrated by radionuclide V/Q lung scanning. A case of albuterol-induced inhibition of hypoxic pulmonary vasoconstriction is described in a patient with steroid-dependent asthma. The utility of V/Q lung scanning as a simple, noninvasive test to detect this phenomenon in patients with primary airway disorders who deteriorate despite appropriate therapy is also briefly discussed.
已知肺泡缺氧会导致局部肺动脉收缩。因此，血液会从不通气良好的肺泡分流，维持通气/灌注（V/Q）匹配，从而减少对气体交换的有害影响。通过放射性核素V/Q肺扫描可以很容易地证明肺泡缺氧性血管收缩反应不完全。本文描述了一例沙丁胺醇诱导的对缺氧性肺血管收缩的抑制作用，该病例为一名依赖类固醇的哮喘患者。还简要讨论了V/Q肺扫描作为一种简单、无创的检测方法，在尽管接受了适当治疗但病情仍恶化的原发性气道疾病患者中检测这种现象的实用性。
