Dabancens A, Zipper J, Guerrero A
Department of Experimental Medicine, Faculty of Medicine, Universidad de Chile, Santiago.
Contraception. 1994 Sep;50(3):243-51. doi: 10.1016/0010-7824(94)90070-1.
Changes in the evolution of a malignant transplantable tumor in mice to whom quinacrine, copper and zinc were supplied in drinking water are reported. Male AJ mice were inoculated in the right thigh with 1,000,000 TA3 or TA3 MTXR tumoral cells. Three experiments were designed with different types of tumors and different schedules of quinacrine and cations administered in drinking water. The animals that received quinacrine or quinacrine plus copper in drinking water had significantly smaller tumors, and some groups had a high rate of complete tumor regression (up to 60%). Quinacrine and copper have synergistic antineoplastic activity. Zinc salts do not improve the antitumoral effect of quinacrine. The relevant fact of this experiment lies in the fact that a large number of women using IUDs with copper could occasionally be treated with quinacrine.
报告了在饮用水中添加奎纳克林、铜和锌的小鼠体内可移植恶性肿瘤的演变变化。雄性AJ小鼠右大腿接种100万个TA3或TA3 MTXR肿瘤细胞。设计了三个实验，采用不同类型的肿瘤以及饮用水中奎纳克林和阳离子的不同给药方案。饮用水中接受奎纳克林或奎纳克林加铜的动物肿瘤明显较小，一些组肿瘤完全消退率很高（高达60%）。奎纳克林和铜具有协同抗肿瘤活性。锌盐不能提高奎纳克林的抗肿瘤效果。该实验的相关事实在于，大量使用含铜宫内节育器的女性偶尔可用奎纳克林治疗。
